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Dairy Intake and Human Disease
Dairy Consumption and Diabetes Risk
Simin Liu, MD, ScD
Recent Metabolic And Epidemiologic Studies Indicate That Intake Of Dairy Products May Lower Risk Of Metabolic Syndrome And Type 2 Diabetes. Herein I Summarize Findings From A Series Of Dietary Studies Of Several Large Populations Of Men And Women. It Appears That Dairy Products And Other Seemingly Independent Beneficial Factors (High Fiber/Whole Grains/Nuts/Fruits/Vegetables/Fish) Are Part Of A Low-Glycemic Load Dietary Pattern That Affects Glucose Homeostasis, Which May Have Beneficial Effects On Vascular Health And May Be Modified By Body Weight And Sex. To Speculate On Mechanisms Whereby Dairy Products May Exert Their Effects On Diabetes Risk, I Further Review Some Plasma Based Studies Of Hormones And Diabetes Risk In Women.

Dairy Consumption and Long-Term Weight Gain
Frank B. Hu. MD, PhD

The Role Of Calcium In The Maintenance Of Body Weight Remains Controversial. We Investigated The Association Between Calcium And Dairy Intakes And 12-Y Weight Change In Us Men, With Data From The Health Professionals Follow-Up Study, A Prospective Cohort Of Men Aged 40-75y In 1986.

Dietary Dairy Intake and Risk of Teenage Acne
Clement Adebamowo, MD

Data Will Be Presented Supporting An Association Between Dietary Intake Of Milk And Risk Of Teenage Acne Explored In 2 Cohorts, Nhs Ii And Guts. We Suggest That This Is Mediated Through Endogenous Or Exogenous Effects On The Igf1 Pathway.

Milk Intake and Risk of Breast Cancer
Walter Willett, MD, DrPH

The relation between growth rates during childhood and attained height in relation to breast cancer will be reviewed. In addition, epidemiologic data on the relation between consumption of milk and some of its constituents during different periods of life and risk of breast cancer will be described.

Calcium and Dairy Intake and Risk of Prostate Cancer
Edward Giovannucci, MD, ScD

In a number of studies, men with higher intake of calcium or milk appear to be at increased risk of prostate cancer. Recent studies indicate that the association may be more relevant for prostate cancer progression than for incidence. This evidence will be reviewed, with a focus on whether the increased risk is more closely associated with calcium or with other correlated factors in milk and dairy products.

Milk, Calcium, Vitamin D and Colorectal Neoplasia
John A. Baron, MD

The presentation will summarize the associations between milk intake and risk of colorectal cancer and colorectal adenomas. Associations with intake of calcium and vitamin D status will also be discussed.

Dairy Products, Calcium, Vitamin D, Lactose and Ovarian Cancer:
Results from a Pooled Analysis of Cohort Studies
Stephanie Smith-Warner, PhD

The associations between intakes of dairy products, calcium, vitamin D, and lactose and the risk of ovarian cancer were examined in the Pooling Project of Prospective Studies of Diet and Cancer, an international consortium of cohort studies. The study population for these analyses consisted of 553,217 women among whom 2,132 were diagnosed with epithelial ovarian cancer. Overall, no associations were observed for intakes of specific dairy foods or calcium and ovarian cancer risk; a modest elevation in the risk of ovarian cancer was observed for lactose intake.

Dairy Foods and Colorectal and Ovarian Cancer - Good and Bad Sides of Milk Foods
Alicja Wolk, DrMedSc

In the search for biomarkers of fat intake we found that fatty acids such as pentadecanoic (C15:0) and conjugated linoleic acid (CLA), which cannot be synthesized by humans, measured in adipose tissue (AT) are valid biomarkers for milk fat intake. Correlations of A T content of C15:0 and CLA with food records were 0.6 and 0.4 respectively. Correlations between food frequency (FFQ)-based and food record-based estimates of consumption of specific dairy foods ranged from 0.4 - 0.6. Using FFQ-based data we found in a population-based cohort of 60,000 Swedish women followed-up during 15 years an inverse association between high-fat dairy foods (butter, cheese, full-fat cultured milk) as well as CLA intake and risk of colorectal cancer. In the same cohort of women, we observed an increased risk of serous epithelial ovarian cancer (but not other subtypes) associated with intake of lactose and dairy products, particularly milk. Taking into account validity of FFQ-based intake estimates true associations of colorectal and ovarian cancers with dairy products are expected to be stronger.

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