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List of questions displayed in video:

  1. Many human studies have found an association between high birth weight and increased breast cancer risk later in life. What did you find when you looked at this in your experimental model of breast cancer in the rat?
  2. Did you find any changes in the mammary glands of the high birth weight rats as compared to the normal rats in your model?
  3. The link then between higher birth weight and higher breast cancer risk in your animal models is the number of terminal end buds?
  4. What happens to these terminal end buds during development, for example, between puberty and pregnancy?
  5. What do you mean by differentiates?
  6. What do your findings tell us about human breast cancer?
  7. What mechanisms in utero might underlie the relationship between higher birth weight and the presence later in life of less differentiated breast tissue?
  8. What types of fetal exposures might affect the expression levels of genes involved in mammary differentiation such that later in life, in response to normal developmental cues, higher or lower levels occur than would otherwise be expected?

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